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Image Guided Cryoablation of Cancer with Intra-Tumor Injection of anti-CTLA-4 and PD-1 Immune Checkpoint Inhibitors. Alternative Treatments for Cancer
Thermal ablation of tumors; biological mechanisms and advances in therapy.
Saponin-based adjuvants create a highly effective anti-tumor vaccine when combined with in situ tumor destruction.
Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy.
Intratumoral Anti-CTLA-4 Therapy: Enhancing Efficacy While Avoiding Toxicity.
Controlled Local Delivery of CTLA-4 Blocking Antibody Induces CD8þ T-Cell–Dependent Tumor Eradication and Decreases Risk of Toxic Side Effects
Cyclophosphamide Unmasks an Antimetastatic Effect of Local Tumor Cryoablation.
Off-Label Propanolol Reduces Melanoma Recurrence
Intratumoral Immunization: A New Paradigm for Cancer Therapy
Immuno-thermal ablations – boosting the anticancer immune response
Human trials are set to commence after a potential cancer vaccine was shown to eliminate all traces of tumors in mice.